Structural Biology
Indiana University School of Medicine
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Center for Structural Biology Indiana University School of Medicine |
What We Are
The Center for Structural Biology is a multi-disciplinary center for experimental investigations designed to examine the structural and functional characteristics of biological macromolecules and how these changes in these properties relate to specific diseases. Direct structure determination through X-ray crystallographic approaches is the primary means by which we obtain much of this information on single proteins or their complexes with nucleic acid or of multi-component protein complexes. Most of us are also involved in efforts to identify small molecule modulators of biological activity through high-throughput discovery approaches, with the goal of characterizing the structure of these modulators bound to their respective targets. Projects currently under investigation are examining the underlying mechanisms for alcoholism, cancer, diabetes, liver and heart disease.
Who We Are
The Center for Structural Biology is currently comprised of the following faculty members from the Department of Biochemistry and Molecular Biology.
William Bosron, Ph.D. - Co-Investigator
Millie Georgiadis, Ph.D. - Co-Investigator
Thomas Hurley, Ph.D. - Center Director
Samy Meroueh, Ph.D. - Co-Investigator and Member, Center for Computational Biology and Bioinformatics
Yuichiro Takagi, Ph.D. - Co-Investigator
Qi-Zhuang Ye, Ph.D. - Co-Investigator
Zhong-Yin Zhang, Ph.D. - Co-Investigator and Chair of Biochemistry and Molecular Biology
Structural Tools in the Center
X-Ray Crystallography
The instrument pictured above is a RAXIS IV++ Image Plate detector for collection of X-ray diffraction data.
The image above shows the Biacore 3000 instrument for characterizing the interactions between macromolecules and their ligands/targets.
